<p>In this talk, we present a thermodynamically consistent two-species micro-macro model of wormlike micellar solutions by employing an energetic variational approach. The model incorporates a breakage and combination process of polymer chains into the classical micro-macro dumbbell model of polymerc fluids in a unified variational framework. The modeling approach can be applied to other chemomechanical systems. Different maximum entropy closure approximations to the micro-macro model will be discussed. By imposing a proper dissipation in the coarse-grained level, the closure model, obtained by “closure-then-variation”, preserves the thermodynamical structure of both mechanical and chemical parts of the original system. The same modeling approach can be applied to many active or reactive systems found in biology. This is joint work with Prof. Chun Liu (IIT) and Dr. Teng-Fei Zhang (CUG).</p>