Heterogeneous catalysts enable many chemical transformations of fossil as well as renewable resources into useful products. At Amsterdam, we try to develop solid catalysts for several types of reactions including CO2 activation, lower alkane activation and biomass conversion. In this talk, I will give an overview of our recent projects on the development of solid catalysts for commercially important reactions. One or two examples in which structural features of catalysts strongly influence their catalytic performance for lower alkane activation will be also discussed in detail.